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KMID : 1137020090200020086
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Journal of Gynecologic Oncology
2009 Volume.20 No. 2 p.86 ~ p.90
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Role of high risk-human papilloma virus test in the follow-up of patients who underwent conization of the cervix for cervical intraepithelial neoplasia
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Park Jeong-Yeol
Bae Jae-Man
Lim Myong-Cheol
Lim So-Yi
Lee Dong-Ock
Kang Sok-Bom
Park Sang-Yoon
Seo Sang-Soo
Nam Byung-Ho
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Abstract
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Objective: To examine whether the presence of high risk-human papilloma virus (HR-HPV) after conization of the cervix was a risk factor for persistence or recurrence of cervical intraepithelial neoplasia (CIN) and whether HR-HPV test could be a guideline for post-therapy surveillance.
Methods: The study retrospectively analyzed data from 243 patients who underwent LLETZ or CKC of the cervix due to CIN.
Results: A positive HR-HPV test result which was performed between 3 and 6 months after procedure was a risk factor for persistent or recurrent cytological (p<0.001, odds ratio [OR]=22.51, 95% confidence interval [CI]=9.74-52.02) and pathological (p<0.001, OR=18.28, 95% CI=5.55-60.20) abnormalities.
Conclusion: HR-HPV positive patients between 3 and 6 months after procedure should undergo frequent and meticulous post-therapy surveillance, while HR-HPV negative patients do not require such high-level surveillance and could undergo routine surveillance.
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KEYWORD
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HR-HPV, Conization, CIN, Recurrence
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